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PINT is a Protein-protein Interactions Thermodynamic Database.

Protein-protein interactions play a key role in many biological processes such as signal transduction, gene expression control, antibody-antigen complex etc. The integration of structural data and thermodynamic parameters of protein-protein complexes would improve our knowledge and pave a way to understand their binding specificity and functions. To achieve this purpose, we have developed this database, PINT.

PINT contains experimental data of several thermodynamic parameters along with literature, sequence and structural information and experimental conditions. Each entry contains the name and source of the proteins involved in binding, their PIR, SWISS-PROT and PDB codes, secondary structure and solvent accessibility of mutant positions and experimental conditions.

The "Text Search" and "Advanced Search" options provide the necessary tools to extract data from PINT.

The "Tutorial" page illustrates how to optimize your query, search the PINT database and retrieve the data.

Number of Data

1700 interactions

Number of Proteins

Data for 140 protein complexes

Number of References

Data from 72 articles

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